Division I
Region 1
1. Mentor (13-0) vs. 7. Lakewood St. Edward (8-5) at Bedford High School Bearcat Stadium
Region 2
2. Centerville (10-3) vs. 8. Huber Heights Wayne (8-5) at Dayton Welcome Stadium
Region 3
1. Powell Olentangy Liberty (11-2) vs. 7. Pickerington North (11-2) at Historic Crew Stadium
Region 4
1. Cincinnati Archbishop Moeller (12-1) vs. 6. Cincinnati St. Xavier (10-3) at Mason High School Tri-Health/Beacon Stadium
Division II
Region 5
1. Cuyahoga Falls Walsh Jesuit (13-0) vs. 2. Akron Archbishop Hoban (11-2) at Twinsburg High School Tiger Stadium
Region 6
1. Avon (13-0) vs. 2. Medina Highland (13-0) at Elyria Charities Field at Ely Stadium
Region 7
1. Sunbury Big Walnut (12-1) vs. 3. Massillon Washington (10-2) at Mansfield Arlin Field
Region 8
1. Cincinnati Anderson (13-0) vs. 2. Cincinnati La Salle (11-2) at Cincinnati Princeton High School Jake Sweeney Automotive Stadium
Division III
Region 9
1. Youngstown Ursuline (12-1) vs. 2. Gates Mills Gilmour Academy (12-1) at Ravenna High School Portage Community Bank Stadium Harry Gilchrist Field
Region 10
1. Toledo Central Catholic (12-1) vs. 7. Parma Padua Franciscan (8-5) at Sandusky High School Foundation Stadium
Region 11
1. Columbus Bishop Watterson (13-0) vs. 2. Steubenville (12-0) at New Philadelphia High School Quaker Stadium
Region 12
4. London (13-0) vs. 3. Bellbrook (12-1) at Springfield High School Wildcat Stadium
Division IV
Region 13
2. Perry (12-1) vs. 5. Cleveland Glenville (10-3) at Macedonia Nordonia High School Boliantz Stadium
Region 14
1. Sandusky Perkins (12-1) vs. 3. Ontario (12-1) at Tiffin Columbian Frost-Kalnow Stadium
Region 15
1. St. Clairsville (13-0) vs. 2. Gnadenhutten Indian Valley (13-0) at Zanesville High School Sulsberger Stadium
Region 16
5. Cincinnati Taft (11-2) vs. 10. Kettering Archbishop Alter (8-5) at Monroe High School Hornet Stadium
Division V
Region 17
1. Canfield South Range (13-0) vs. 3. Poland Seminary (11-2) at Boardman High School
Region 18
1. Milan Edison (13-0) vs. 2. Liberty Center (13-0) at Millbury Lake High School Community Stadium
Region 19
1. Ironton (12-1) vs. 14. Wheelersburg (9-4) at South Point High School Alumni Field
Region 20
2. West Liberty-Salem (12-1) vs. 5. Lewistown Indian Lake (11-2) at Piqua High School Alexander Stadium
Division VI
Region 21
1. Kirtland (13-0) vs. 6. Dalton (10-3) at North Royalton High School Serpentini Stadium
Region 22
2. Bluffton (12-1) vs. 4. Hamler Patrick Henry (11-2) at Findlay Donnell Stadium
Region 23
1. Columbus Grandview Heights (12-0) vs. 2. Galion Northmor (13-0) at Westerville Central High School
Region 24
1. Coldwater (12-1) vs. 3. Anna (10-3) at Sidney Memorial Stadium
Division VII
Region 25
2. Jeromesville Hillsdale (12-1) vs. 9. Cuyahoga Heights (8-4) at Orrville Red Rider Stadium, Heartland Field
Region 26
1. Columbus Grove (13-0) vs. 15. Delphos St. John’s (6-7) at Lima Spartan Stadium
Region 27
1. Danville (11-2) vs. 2. Beaver Eastern (13-0) at Logan High School Chieftain Stadium
Region 28
1. Maria Stein Marion Local (13-0) vs. 2. Minster (11-2) at Wapakoneta High School Mercy Health Wapak VFW Field
